USING BIOINFORMATICS APPROACHES TO IDENTIFY SURVIVAL-RELATED ONCOMIRS AS POTENTIAL TARGETS OF MIRNA-BASED TREATMENTS FOR LUNG ADENOCARCINOMA

Using bioinformatics approaches to identify survival-related oncomiRs as potential targets of miRNA-based treatments for lung adenocarcinoma

Lung cancer is a major cause of cancer-associated deaths worldwide, and lung adenocarcinoma (LUAD) is the most common lung cancer subtype.Micro RNAs (miRNAs) regulate the pattern of gene expression in multiple cancer types and have been explored as potential drug development targets.To develop an oncomiR-based panel, we identified miRNA candidates

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Temporal and spatial resolution of activated plant defense responses in leaves of Nicotiana benthamiana infected with Dickeya dadantii

The necrotrophic bacteria Dickeya dadantii is the causal agent of soft-rot disease in a broad range of hosts.The model plant Nicotiana benthamiana, commonly used as experimental host for a very broad range of plant pathogens, is susceptible to infection by D.dadantii.The inoculation with D.dadantii at high dose seems to overcome the plant defense c

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The Explanation-Polarisation Model: Pseudoscience Spreads Through Explanatory Satisfaction and Group Polarisation

This article presents an integrative model for the endorsement of pseudoscience: the explanation-polarisation model.It is based on a combination of perceived explanatory satisfaction and group polarisation, offering a here perspective different from the classical confusion-based conception, in which pseudoscientific beliefs would be accepted throug

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